Diffuse Large B Cell Lymphoma Mimicking Ulceroproliferative Lesion

Abstract

Introduction: The oropharynx contains abundant lymphoid tissue, particularly in the palatine and lingual tonsils, which form the anterolateral components of Waldeyer's ring. Lymphomas arising in the oropharynx are almost exclusively Non-Hodgkin lymphoma and originate from lymphoid tissue.

Methods: A case of a 69-year-old male with Non-Hodgkin lymphoma of the oropharynx is presented, discussing the clinical features, radiological findings, histopathological findings, and management.

Discussion: Most patients with Non-Hodgkin lymphoma present with neck swellings. Although infections and inflammatory conditions may also cause lymphadenopathy, timely clinical examination and appropriate investigations facilitate early diagnosis and treatment.

Results: The patient presented with neck swelling, odynophagia, and dysphagia, clinically mimicking oropharyngeal squamous cell carcinoma. Punch biopsy confirmed Diffuse Large B Cell Lymphoma (DLBCL). Chemotherapy using the R-CHOP regimen was initiated, but the patient succumbed to the disease because of its poor prognosis.

Conclusion: Non-Hodgkin lymphoma of the oropharynx can mimic squamous cell carcinoma. Improved patient awareness and earlier detection may reduce mortality. DLBCL carries a poor prognosis.