Primary Laryngeal Amyloidosis – A Case Report

Abstract

Dysphonia is a common symptom in otolaryngology, usually linked to benign or functional causes, but it can rarely be the sole presentation of infiltrative conditions such as laryngeal amyloidosis, often leading to misdiagnosis due to nonspecific clinical and radiologic features. 
We report a 60-year-old woman with three months of progressive dysphonia without airway or systemic symptoms. Laryngoscopy revealed yellowish submucosal polypoidal lesions over the right vestibular band and both vocal cords, and neck imaging showed enhancing supraglottic lesions. She underwent CO₂ laser–assisted microlaryngoscopic excision, allowing precise removal with mucosal preservation. Histopathology confirmed amyloidosis, and systemic workup ruled out generalized disease, establishing primary localized laryngeal amyloidosis. Postoperatively, the patient experienced marked improvement in voice quality and remains disease-free on follow-up. 
This case underscores the need to consider rare etiologies in isolated dysphonia and highlights CO₂ laser excision as an effective treatment providing excellent functional outcomes.