Will Biological Therapy become a Game Changer in Chronic Rhinosinusitis

Abstract

Chronic rhinosinusitis (CRS) poses a significant burden on the global health. The incidence of CRS is 5-12 % in the western world. The understanding about chronic rhinosinusitis has changed considerably over the years. The currently available treatment options like antibiotics, corticosteroids and surgery provide relief in most of the patients. However, a subset of patients come with recalcitrant disease. Recurrent chronic rhinosinusitis with nasal polyposis (CRSwNP) present a depressing situation to the treating clinician.